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Disease Profile
Staphylococcal toxic shock syndrome
Prevalence
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
1-9 / 100 000
Age of onset
All ages
ICD-10
A48.3
Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Other names (AKA)
Bacterial toxic-shock syndrome
Summary
The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.
Orpha Number: 36234
Definition
Bacterial toxic shock syndrome (TSS) is a potentially fatal, acute disease characterized by a sudden onset of high fever along with nausea, myalgia, vomiting and multisystem organ involvement, potentially leading to shock and death. TSS is mediated by superantigenic toxins , usually caused by an infection with Staphylococcus aureus in staphylococcal TSS (see this term) or Streptococcus pyogenes in streptococcal TSS (see this term).
Epidemiology
The worldwide prevalence is estimated at 1/30, 000.
The disease affects mainly young adult women with no previous medical conditions. However, non-menstrual TSS, which can also be observed in men and children, represents up to 50% of Staphylococcal TSS cases. Onset is sudden and includes high fever (>38.9°C), nausea, diarrhea, vomiting, myalgia, abdominal pain and sore throat. Staphylococcal TSS almost always exhibits an erythematous rash and skin peeling as one of its manifestations, whereas it is very rarely seen in streptococcal TSS, which can show signs of soft tissue infection. Serious manifestations include confusion, shock, renal and myocardial dysfunction, acute respiratory distress syndrome (ARDS; see this term) and coma.
Staphylococcal TSS is due to an infection with Staphylococcus aureus and streptococcal TSS is due to an infection with Streptococcus pyogenes, or rarely, group C or G Streptococcus. Superantigens produced by both bacteria are responsible for the massive and sudden immune reaction seen in TSS. Both forms have been associated with recent traumas (surgery or childbirth) and viral infections, while staphylococcal TSS has also been associated with high absorbency tampon use.
Visit the Orphanet disease page for more resources.
Symptoms
This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
| Medical Terms | Other Names |
Learn More:
HPO ID
|
|---|---|---|
| 80%-99% of people have these symptoms | ||
| Hypotension |
Low blood pressure
|
0002615 |
| Shock | 0031273 | |
| 30%-79% of people have these symptoms | ||
| Abdominal pain |
Pain in stomach
Stomach pain
[ more ] |
0002027 |
| Abnormality of facial soft |
Anomaly of facial soft tissue
|
0011799 |
| Confusion |
Disorientation
Easily confused
Mental disorientation
[ more ] |
0001289 |
| Fasciitis |
Inflammation of the fascia
|
0100537 |
| Fever | 0001945 | |
| Increased serum lactate | 0002151 | |
| Metabolic acidosis | 0001942 | |
| Myalgia |
Muscle ache
Muscle pain
[ more ] |
0003326 |
| Recurrent skin infections |
Skin infections, recurrent
|
0001581 |
| Respiratory distress |
Breathing difficulties
Difficulty breathing
[ more ] |
0002098 |
| Tachycardia |
Fast heart rate
Heart racing
Racing heart
[ more ] |
0001649 |
| 5%-29% of people have these symptoms | ||
| Abnormal blistering of the skin |
Blistering, generalized
Blisters
[ more ] |
0008066 |
| Abnormality of the lower limb |
Lower limb deformities
|
0002814 |
| Abnormality of the upper limb | 0002817 | |
| Abscess | 0025615 | |
| Acute cutaneous wound | 0032675 | |
| Bacteremia | 0031864 | |
| Capillary leak | 0030005 | |
| Cellulitis |
Bacterial infection of skin
Skin infection
[ more ] |
0100658 |
| Chills | 0025143 | |
| Diarrhea |
Watery stool
|
0002014 |
| Disseminated intravascular coagulation | 0005521 | |
| Ecchymosis | 0031364 | |
| Elevated serum creatine kinase |
Elevated blood creatine phosphokinase
Elevated circulating creatine phosphokinase
Elevated creatine kinase
Elevated serum CPK
Elevated serum creatine phosphokinase
High serum creatine kinase
Increased CPK
Increased creatine kinase
Increased creatine phosphokinase
Increased serum CK
Increased serum creatine kinase
Increased serum creatine phosphokinase
[ more ] |
0003236 |
| Elevated serum creatinine |
Elevated creatinine
High blood creatinine level
Increased creatinine
Increased serum creatinine
[ more ] |
0003259 |
| Encephalitis |
Brain inflammation
|
0002383 |
| Glomerulonephritis | 0000099 | |
| Hepatitis |
Liver inflammation
|
0012115 |
| Hypoalbuminemia |
Low blood albumin
|
0003073 |
| Hypocalcemia |
Low blood calcium levels
|
0002901 |
| Increased circulating metamyelocyte count | 0032238 | |
| Increased circulating myelocyte count | 0032237 | |
| Localized skin lesion | 0011355 | |
| 0001287 | ||
| Myocarditis |
Inflammation of heart muscle
|
0012819 |
| Myositis |
Muscle inflammation
|
0100614 |
| Nausea | 0002018 | |
| Osteomyelitis |
Bone infection
|
0002754 |
| Peritonitis | 0002586 | |
| Pharyngitis | 0025439 | |
| Pneumonia | 0002090 | |
| Renal insufficiency |
Renal failure
Renal failure in adulthood
[ more ] |
0000083 |
| Scaling skin |
flaking skin
peeling skin
scaly skin
[ more ] |
0040189 |
| Sepsis |
Infection in blood stream
|
0100806 |
| Septic |
0003095 | |
| Severe varicella zoster infection | 0032170 | |
| Sinusitis |
Sinus inflammation
|
0000246 |
| Skin rash | 0000988 | |
| Tachypnea |
Increased respiratory rate or depth of breathing
|
0002789 |
|
Low platelet count
|
0001873 | |
| Vomiting |
Throwing up
|
0002013 |
| 1%-4% of people have these symptoms | ||
| Edema |
Fluid retention
Water retention
[ more ] |
0000969 |
| Recurrent urinary tract infections |
Frequent urinary tract infections
Repeated bladder infections
Repeated urinary tract infections
Urinary tract infections
Urinary tract infections, recurrent
[ more ] |
0000010 |
Learn more
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
In-Depth Information
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.