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5 Facts you should know about
Activated PI3K delta syndrome (APDS)
1
APDS, a primary immunodeficiency, was only characterized in 2013, although it shares many features of other immune disorders, which means APDS patients may have been previously misdiagnosed with other conditions
2
Signs and symptoms of APDS start in childhood, and patients are vulnerable to repeat infections and immune dysregulation such as lymphadenopathy, splenomegaly, autoimmune cytopenias, and even lymphoma
3
Initially, patients with APDS may seek care from hematologists because of swollen lymph nodes or low numbers of blood cells
4
Overproduction of B and T cells has been shown to appear as swollen tonsils, lymphadenopathy, or a swollen spleen
5
Genetic testing is the only way to definitively diagnose APDS and other primary immunodeficiencies that could lead to potentially fatal disorders like lymphoma
Rare Hematology News
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